Clearly, reduction of sperm DNA checking for sperm dna damage prior to assisted reproductive technology ART should be recommended to reduce the disease-risk for the offspring. Journal List Transl Androl Urol v. This guideline is extremely relevant for fertility specialists and further insight into the topic is in high demand as the debate regarding the role of DNA damage testing is still ongoing 23. However, several clinical studies subsequently demonstrated that this is not the case checking for sperm dna damage that the outcome of IVF and especially ICSI treatment are less affected than is the case for IUI treatments and natural intercourse. Flow cytometric assessment of sperm DNA damage has been demonstrated to provide highly reliable and precise results 17 The data and recommendations offered in the clinical utility article are at best weak level C evidence in most scenarios. The study by Kong et al. Sperm are very small yet they need to carry massive amounts of genetic information to the egg. Footnotes Conflicts of Interest: Author information Copyright and License information Disclaimer.